#Cardiometabolic Health
Explore evidence-informed monographs, pharmacological mechanisms, traditional ethnobotany, and therapeutic protocols categorized under #Cardiometabolic Health.
Berberine AMPK & PCSK9 Suppression: Hepatic LDL Receptor Upregulation
A scientific monograph on Berberine alkaloid (Berberis vulgaris), analyzing AMPK activation, post-transcriptional LDLR mRNA stabilization via ERK, and PCSK9 protein suppression.
High-Dose EPA Ethyl Esters: Membrane Stabilization & Triglycerides
A scientific monograph on high-dose pure Eicosapentaenoic Acid (EPA Ethyl Esters / Icosapent Ethyl), analyzing membrane cholesterol domain stabilization, triglyceride clearance, and the REDUCE-IT trial.
Red Yeast Rice Monacolin K: HMG-CoA Reductase Inhibition & Citrinin Safety
A scientific monograph on Red Yeast Rice (Monascus purpureus), analyzing natural Monacolin K, reversible HMG-CoA reductase inhibition, ApoB clearance, and certified citrinin-free mycotoxin safety.
Aged Garlic Extract & S-Allylcysteine: Soft Plaque Reversal & Homocysteine
A scientific monograph on Aged Garlic Extract (AGE - Kyolic), evaluating the water-soluble organosulfur compound S-Allylcysteine (SAC), coronary artery soft vulnerable plaque reversal, and arterial stiffness.
Hawthorn Berry Procyanidins (Crataegus): Coronary Vasodilation & Positive Inotropy
A scientific monograph on standardized Hawthorn leaf and flower extract (Crataegus monogyna / oxyacantha - WS 1442), analyzing oligomeric procyanidins, ACE inhibition, coronary vasodilation, and myocardial inotropy.
Coenzyme Q10 (Ubiquinol): Mitochondrial Complexes & Statin Myopathy
A scientific monograph on Coenzyme Q10 (Ubiquinol vs Ubiquinone), evaluating mitochondrial Respiratory Complexes I, II, and III electron shuttling, and statin-induced mevalonate pathway depletion.
The Triglyceride-to-HDL Ratio: Biomarker of Small Dense LDL & Hepatic Steatosis
A scientific monograph on the Triglyceride-to-HDL Ratio (TG/HDL), analyzing its surrogacy for small dense LDL (sdLDL Pattern B), visceral hepatic de novo lipogenesis, and hyperinsulinemia.
eNOS Coupling & L-Citrulline: Endothelial Nitric Oxide & Flow-Mediated Dilation
A scientific monograph on Endothelial Nitric Oxide Synthase (eNOS) uncoupling, evaluating tetrahydrobiopterin (BH4) oxidation, oral L-citrulline vs L-arginine pharmacokinetics, and Flow-Mediated Dilation (FMD).
Apolipoprotein B (ApoB) vs LDL-C: Particle Stoichiometry & Arterial Transcytosis
A scientific monograph on Apolipoprotein B (ApoB), evaluating particle number stoichiometry vs cholesterol mass (LDL-C), arterial endothelial transcytosis, and sub-endothelial retention.