Cold-Pressed Sesame Oil: Sesamin, Sesamol & Endothelial Shielding
The Golden Oil of the Ancient Mesopotamian Cradle
Cultivated in Anatolia and the Fertile Crescent since the dawn of the Bronze Age, Sesame (Sesamum indicum, Pedaliaceae; Turkish: Susam) was described in Babylonian and Assyrian cuneiform tablets as the divine oil that never spoils.- The Unique Sesamin Lignan Complex: Sesame oil contains dense quantities of specialized phenylpropanoid lignans: sesamin and sesamolin. Upon gentle processing or storage, sesamolin hydrolyzes into sesamol, a powerful antioxidant phenol with extraordinary thermal resistance.
- Inhibition of Hepatic Delta-5-Desaturase: Sesamin selectively modulates hepatic fatty acid desaturases, driving the accumulation of anti-inflammatory dihomo-$\gamma$-linolenic acid (DGLA) and shielding circulating low-density lipoproteins (LDL) from oxidative damage.
Interactive Longevity Tools & Related Protocols
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Primary Scientific Citations
- Sankar, D., et al. (2006). Effect of sesame oil on blood pressure and lipid peroxidation in hypertensive patients. Yale Journal of Biology and Medicine, 79(1), 19-26.
- Sirato-Yasumoto, S., et al. (2001). Effect of sesamin and sesamolin on the alpha-tocopherol concentration in rats. Journal of Agricultural and Food Chemistry, 49(11), 5623-5628.
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